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Journal international du cancer, 54, 571–577.Ĭance, W. Novel protein kinases expressed in human breast cancer, International journal of cancer. Biochimica et biophysica acta, 1856, 39–54.Ĭance, W. Tracing the footprints of the breast cancer oncogene BRK-past till present. Given its functional heterogeneity observed across different cancers, we also discuss the therapeutic significance of FRK. This review sheds light on the recent developments emerged from investigations on FRK which include: (a) a review of the expression pattern of the protein in mammalian cells/tissues, (b) underlying genomic perturbations and (c) a mechanistic function of the enzyme across different cellular environments. Such functional paradox is therefore evidently exhibited in a tissue-specific context.

Specifically, while ectopic expression of FRK suppresses cell proliferation and migration in breast and brain cancers, knockdown or catalytic inhibition of FRK suppresses these cellular processes in pancreatic and liver cancer. In recent years, however, further functional characterization of the tyrosine kinase in diverse cancer types suggests that FRK may potentially play an oncogenic role as well. FRK was first discovered in 1993, and studies pursued thereafter attributed a potential tumour-suppressive function to the enzyme. The non-receptor tyrosine kinase Fyn-related kinase (FRK) is a member of the BRK family kinases (BFKs) and is distantly related to the Src family kinases (SFKs).

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